Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics Simulations for Studying Correlates of Prevention Efficacy of Passive HIV-1 Antibody Prophylaxis in the Antibody Mediated Prevention (AMP) Study
A key objective in two phase 2b AMP clinical trials of VRC01 is to evaluate whether drug concentration over time, as estimated by non-linear mixed effects pharmacokinetics (PK) models, is associated with HIV infection rate. We conducted a simulation study of marker sampling designs, and evaluated the effect of study adherence and sub-cohort sample size on PK model estimates in multiple-dose stu...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2020
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1007626